Del Campo, M., Lambowitz, A.M.  Structure of the yeast DEAD-box protein MSS116p reveals two wedges that crimp RNA. Mol. Cell 35:598-609, 2009.

Del Campo, M., Lambowitz, A.M. Crystallization and preliminary X-ray diffraction of the DEAD-box protein Mss116p complexed with an RNA oligonucleotide and AMP-PNP. Acta Crystallogr. F Struct. Biol. Cryst. Commun. 65:832-835, 2009.

Del Campo, M., Mohr, S., Jiang, Y., Jia, H., Jankowsky, E., Lambowitz, A.M.  Unwinding by local strand separation is critical to function of DEAD-Box proteins as RNA chaperones. J. Mol. Biol., 2009.

Markov, D.A., Savkina, M., Anikin, M., Del Campo, M., Ecker, K., Lambowitz, A.M., DeGnore, J.P., McAllister, W.T.  Identification of proteins associated with the yeast mitochondrial RNA polymerase by tandem affinity purification. Yeast 26:423-440, 2009.

Zhuang F., Karberg M., Perutka J., Lambowitz A.M. EcI5, a group IIB intron with high retrohoming frequency: DNA target site recognition and use in gene targeting. RNA,15, 432-449, 2009.

Zhuang, F., Matroianni, M., White, T., Lambowitz, A.M. Linear group II intron RNAs can retrohome in eukaryotes and may use nonhomologous end-joing for cDNA ligation. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 2009.

Chen Y., Potratz J.P., Tijerina P., Del Campo M., Lambowitz A.M., Russell R. DEAD-box proteins can completely separate an RNA duplex using a single ATP. Proc. Natl. Acad. Sci. USA, 105, 20203-20208, 2008.

Dai, L., Chai, D.,   Gu, S-Q.,  Gabel, J., Noskov, S.Y.,  Blocker, F.J., Lambowitz, A.M., Zimmerly, S.  A three-dimensional model of a group II intron RNA and its interaction with the intron-encoded reverse transcriptase. Mol. Cell 30, 472-485, 2008.

Mastroianni, M., Watanabe, K., White, T.B., Zhuang, F., Veron, J., Matsuura, M., Wallingford, J., Lambowitz, A.M. Group II intron-based gene targeting reactions in eukaryotes. PLoS ONE, 3, e3121, 2008.

Mohr, G., Del Campo, M., Mohr, S., Yang, Q., Jia, H., Jankowsky, E., Lambowitz, A.M. Function of the C-terminal domain of the DEAD-box protein Mss116p analyzed in vivo and in vitro. J. Mol. Biol. 375, 1344-13464, 2008.

Paukstelis, P.J., Chen, J.H., Chase, E., Lambowitz, A.M.,Golden, B.L. Structure of a tyrosyl-tRNA synthetase splicing factor bound to a group I intron RNA. Nature 451, 94-97, 2008.

Paukstelis, P.J., Lambowitz, A.M.  Identification and evolution of fungal mitochondrial tyrosyl-tRNA synthetases with group I intron splicing activity. Proc. Natl. Acad. Sci. USA 105, 6010-6015, 2008.

Vicens, Q., Paukstelis, P.J., Westhof, E., Lambowitz, A.M., Cech, T.R.  Toward predicting self-splicing and protein-facilitated splicing of group I introns. RNA 14, 2013-2029, 2008.

Zhao J., Niu, W., Yao, J., Mohr, S., Marcotte, E.M., Lambowitz, A.M. Group II intron protein localization and insertion sites are affected by polyphosphate. PLoS Biol. 6, e150, 2008.

Del Campo, M., Tijerina, P., Bhaskaran, H., Mohr, S., Yang, Q., Jankowsky, E., Russell, R.,  Lambowitz, A.M. Do DEAD-box proteins promote group II intron splicing without unwinding RNA? Mol. Cell. 28, 159-166, 2007.

Yang, Q., Del Campo, M., Lambowitz, A.M., and Jankowsky, E. DEAD-box proteins unwind duplexes by local strand separation. Mol. Cell, 28, 253-263, 2007.

Yao, J., and Lambowitz, A.M. Gene targeting in Gram-negative bacteria by use of a mobile group II intron ("targetron") expressed from a broad-host-range vector. Appl. Environ. Microbiol., 73, 2735-2743, 2007.

Grohman, J.K., Del Campo, M., Tijerina, P., Lambowitz, A.M., and Russell, R. Probing the mechanisms of DEAD-box proteins as general RNA chaperones: the C-terminal domain of CYT-19 mediates general recognition of RNA. Biochemistry, 46, 3013-3022, 2007.

Halls, C., Mohr, S., Del Campo, M., Yang, Q., Jankowsky, E., and Lambowitz, A.M. Involvement of DEAD-box proteins in group I and group II intron splicing. Biochemical characterizatoin of Mss116p, ATP hydrolysis-dependent and -independent mehaniosms and general RNA chaperone activity. J. Mol. Biol., 365, 835-855, 2007.
 
Noah, J.W., Park, S., Whitt, J.T., Perutka, J., Frey, W., and Lambowitz, A.M. Atomic force microscopy reveals DNA bending during group II intron ribonucleoprotein particle integration into double-stranded DNA. Biochemistry, 45, 12424-12435, 2006.

Yao, J., Zhong, J., Fang, Y., Geisinger, E., Novick, R.P., and Lambowitz, A.M. Use of targetrons to disrupt essential and non-essential genes in Staphylococcus aureus reveals temperature-sensitivity of the Ll.LtrB group II intron splicing. RNA, 12, 1271-1281, 2006. 

Mohr, S., Matsuura, M., Perlman, P.S., and Lambowitz, A.M. A DEAD-box protein by itself promotes group II intron splicing and reverse splicing by acting as an RNA chaperone. Proc. Natl. Acad. Sci. USA, 103, 3569-3574, 2006.

Pyle, A.M., and Lambowitz, A.M. Group II introns: ribozymes that splice RNA and invade DNA. In: The RNA World, 3rd Edition (R.F. Gesteland, T.R. Cech, and J.F. Atkins, Editors), Cold Spring Harbor Laboratory Press, pp. 469-505, Cold Spring Harbor, New York, 2006.

Zhao, J., and Lambowitz, A.M. A bacterial group II intron-encoded reverse transcriptase localizes to cellular poles. Proc. Natl. Acad. Sci., USA, 102, 16233-16140, 2005.

Smith, D., Zhong, J., Matsuura, M., Lambowitz, A.M., and Belfort, M. Recruitment of host functions suggests a repair pathway for late steps in group II intron retrohoming. Genes & Dev., 19, 2477-2487, 2005.

Paukstelis, P.J., Coon, R., Madabusi, L., Nowakowski, J., Monzingo, A., Robertus, J., and Lambowitz, A.M. A Tyrosyl-tRNA Synthetase Adapted to Function in Group I Intron Splicing by Acquiring a New RNA-Binding Surface. Mol. Cell, 17, 417-428, 2005.

Lambowitz, A.M., Mohr, G., and Zimmerly, S. Group II intron homing endonucleases: ribonucleoprotein complexes with programmable target specificity. In Nucleic Acids and Molecular Biology, Vol. 16: Homing Endonucleases and Inteins (M. Belfort, V. Derbyshire, B. Stoddard and D. Wood, eds.), pp. 121-145, Springer-Verlag, Heidelberg, 2005.

Coros, C.J., Landthaler, M., Piazza, C.L., Beauregard, A., Esposito, D., Perutka, J., Lambowitz, A.M., and Belfort, M. Retrotransposition strategies of the Lactococcus lactis Ll.LtrB group II intron are dictated by host identity and cellular environment. Mol. Microbiol., 56, 509-524, 2005.

Jones, J.P., III, Kierlin, M.N., Coon, R.G., Perutka, J., Lambowitz, A.M., and Sullenger, B.A. Retargeting mobile group II introns to repair mutant genes. Molecular Therapy, 11, 687-694, 2005.

Yao, J., Zhong, J., and Lambowitz, A.M. Gene targeting using randomly inserted group II introns (targetrons) recovered from an Escherichia coli gene disruption library. Nucl. Acids Res., 10, 3351-3362, 2005.

Blocker, F.J.H., Mohr, G., Conlan, L.H., Qi, L.,Belfort, M. and Lambowitz, A.M. Domain Structure and Three-Dimensional Model of a Group II Intron-Encoded Reverse Transcriptase. RNA 11, 14-28, 2005.

Lambowitz, A.M., and Zimmerly, S. Mobile group II introns. Annu. Rev. Genet. 38, 1-35, 2005.

Huang, H.-R., Rowe, C.E., Mohr, S., Jiang, Y., Lambowitz, A.M., and Perlman, P.S. The splicing of yeast mitochondrial group I and group II introns requires a DEAD-box protein with RNA chaperone function. Proc. Natl. Acad. Sci. USA 102, 163-168, 2005.

Chen, X., Mohr, G., and Lambowitz, A.M. The Neurospora crassa CYT-18 protein C-terminal RNA-binding domain helps stabilize interdomain tertiary interactions in group I introns. RNA, 10, 634-644, 2004.

Cui, X., Matsuura, M., Wang, Q., Ma., H., and Lambowitz, A.M. A group II intron-encoded maturase functions preferentially in cis and requires both the reverse transcriptase and X domains to promote RNA splicing. J. Mol. Biol., 340, 211-231, 2004.

Perutka, J., Wang, W., Goerlitz, D., and Lambowitz, A.M. Use of computer-designed group II introns to disrupt Escherichia coli DExH/D-box protein and DNA helicase genes. J. Mol. Biol., 336, 421-439, 2004

Watanabe, K., and Lambowitz, A.M. High-Affinity Binding Site for a Group II Intron-Encoded Reverse Transcriptase/Maturase Within a Stem-Loop Structure in the Intron RNA. RNA 10, 1433-1444, 2004.

Aizawa, Y., Xiang, Q., Lambowitz, A.M., and Pyle, A.M. The pathway for DNA recognition and RNA integration by a group II intron retrotransposon. Mol. Cell, 11, 795-805, 2003.

Frazier, C.L., San Filippo, J., Lambowitz, A.M., and Mills, D.A. Genetic manipulation of Lactococcus lactis using targeted group II introns: generation of stable insertions without selection. Appl. Environ. Microbiol., 69, 1121-1128, 2003.

Huang, M.-R., Chao, M.Y., Armstrong, B., Wang, Y., Lambowitz, A.M., and Perlman, P.S. The DIVa maturase binding site in the yeast group II intron aI2 is essential for intron homing but not for in vivo splicing. Mol. Cell. Biol., 23, 8809-8819, 2003.

Mohr, G., and Lambowitz, A.M. Putative proteins related to group II intron reverse transcriptase/maturases are encoded by nuclear genes in higher plants. Nucl. Acids. Res., 31, 647-652, 2003.

Muñoz-Adelantado, E., San Filippo, J., Martínez-Abarca, F., García-Rodríguez, F.M., Lambowitz, A.M., and Toro, N. Mobility of the Sinorhizobium meliloti group II intron RmInt1 occurs by reverse splicing into DNA targets, but requires an unknown reverse transcriptase priming mechanism. J. Mol. Biol., 327, 931-943, 2003.

Noah, J.W., and Lambowitz, A.M. Effects of maturase binding and Mg²⁺ concentration on group II intron RNA folding investigated by UV-cross-linking. Biochemistry, 42, 12466-12480, 2003.

Zhong, J., and Lambowitz, A.M. Group II intron mobility using nascent strands at DNA replication forks to prime reverse transcription. EMBO J., 22, 4555-4565, 2003.

Zhong, J., Karberg, M., and Lambowitz, A.M. Targeted and random bacterial gene disruption using a group II intron (targetron) vector containing a retrotransposition-activated selectable marker. Nucl. Acids Res., 31, 1656-1664, 2003.

Belfort, M., Derbyshire, V., Parker, M.M., Cousineau, B., and Lambowitz, A.M. Mobile introns: pathways and proteins. In: Mobile DNA II (N.L. Craig, R. Craigie, M. Gellert, and A.M. Lambowitz, eds.), pp. 761-783, ASM Press Publishers, Washington D.C., 2002.

Mohr, S., Stryker, J., and Lambowitz, A.M. A DEAD-box protein functions as an ATP-dependent RNA chaperone in group I intron splicing. Cell, 109, 769-779, 2002.

Myers, C.A., Kuhla, B., Cusack, S., and Lambowitz, A.M. tRNA-like recognition of group I introns by a tyrosyl-tRNA synthetase. Proc. Natl. Acad. Sci., USA, 99, 2630-2635, 2002.

San Filippo, J., and Lambowitz, A.M., Characterization of the C-terminal RNA-binding/DNA endonuclease region of a group II intron-encoded protein. J. Mol. Biol., 324, 933-951, 2002.

Singh, R.A., Saldanha, R.J., D'Souza, L.M., and Lambowitz, A.M. Binding of a group II intron-encoded reverse transcriptase/maturase to its high affinity intron RNA binding site involves sequence-specific recognition and autoregulates translation. J. Mol. Biol. 318, 287-303, 2002.

Caprara, M.G., Myers, C.A., and Lambowitz, A.M. Interaction of the Neurospora crassa mitochondrial tyrosyl-tRNA synthetase (CYT-18 protein) with the group I intron P4-P6 domain. Thermodynamic analysis and the role of metal ions. J. Mol. Biol. 308, 165-190, 2001.

Dickson, L., Huang, H., Liu, L., Matsuura, M., Lambowitz, A.M. and Perlman, P.S. Retrotransposition of a yeast group II intron occurs by reverse splicing directly into ectopic DNA sites. Proc. Natl. Acad. Sci., USA, 98, 13207-13212, 2001.

Karberg, M., Guo, H., Zhong, J., Coon, R., Perutka, J., and Lambowitz, A.M. Group II introns as controllable gene targeting vectors for genetic manipulation of bacteria. Nature Biotech. 19, 1162-1167, 2001.

Matsuura, M., Noah, J.W., and Lambowitz, A.M. Mechanism of maturase-promoted group II intron splicing. EMBO J. 20, 7259-7270, 2001.

Mohr, G., Rennard, R., Cherniack, A.D., Stryker, J., and Lambowitz, A.M. Function of the Neurospora crassa mitochondrial tyrosyl-tRNA synthetase in RNA splicing. Role of the idiosyncratic N-terminal extension and different modes of interaction with different group I introns. J. Mol. Biol. 307, 75-92, 2001.

Singh, N.N. and Lambowitz, A.M. Interaction of a group II intron ribonucleoprotein endonuclease with its DNA target site investigated by DNA footprinting and modification interference. J. Mol. Biol. 309, 361-386, 2001.

Chen, X., Gutell, R.R., and Lambowitz, A.M. Function of tyrosyl-tRNA synthetase in splicing group I introns. An induced fit model for binding to the P4-P6 domain based on analysis of mutations at the junction of the P4-P6 stacked helices. J. Mol. Biol. 301, 265-283, 2000.

Eskes, R., Liu, L., Ma, H., Chao, M.Y., Dickson, L., Lambowitz, A.M. and Perlman, P.S. Multiple homing pathways used by yeast mitochondrial group II introns. Mol. Cell. Biol. 20, 8432-8446, 2000.

Guo, H., Karberg, M., Long, M., Jones, J.P. III, Sullenger, B., and Lambowitz, A.M. Group II introns designed to insert into therapeutically-relevant DNA target sites in human cells. Science, 289, 452-457, 2000.

Mohr, G., Smith, D., Belfort, M., and Lambowitz, A.M. Rules for DNA target-site recognition by a lactococcal group II intron enable retargeting of the intron to specific DNA sequences. Genes & Devel. 14, 559-573, 2000.

Mohr, S., Wanner, L.A., Bertrand, H., and Lambowitz, A.M. Characterization of an unusual tRNA-like sequence found inserted in a Neurospora retroplasmid. Nucl. Acids Res. 28, 1514-1524, 2000.

Lambowitz, A.M., Caprara, M.G., Zimmerly, S., and Perlman, P.S. Group I and group II ribozymes as RNPs: clues to the past and guides to the future. In: The RNA World, Second Edition (R.F. Gesteland, T.R. Cech, and J.F. Atkins, Editors), pp. 451-485, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 1999.

Saldanha, R., Chen, B., Wank, H., Matsuura, M., Edwards, J., and Lambowitz, A.M. RNA and protein catalysis in group II intron splicing and mobility reactions using purified components. Biochemistry, 38, 9069-9083, 1999.

Wank, H., San Filippo, J., Singh, R.N., Matsuura, M., and Lambowitz, A.M. A reverse transcriptase/maturase promotes splicing by binding at its own coding segment in a group II intron RNA. Mol. Cell, 4, 239-250, 1999.

Zimmerly, S., Moran, J.V., Perlman, P.S., and Lambowitz, A.M. Group II intron reverse transcriptase in yeast mitochondria. Stabilization and regulation of reverse transcriptase activity by the intron RNA. J. Mol. Biol. 289, 473-490, 1999.

Cousineau, B., Smith, D., Lawrence-Cavanagh, S., Mueller, J.E., Yang, J., Mills, D., Manias, D., Dunny, G., Lambowitz, A.M., and Belfort, M., Retrohoming of a bacterial group II intron: mobility via complete reverse splicing independent of homologous recombination. Cell, 94, 451-462, 1998.

Yang, J., Mohr, G., Perlman, P.S., and Lambowitz, A.M. Group II intron mobility in yeast mitochondria: target DNA-primed reverse transcription activity of aI1 and reverse splicing into DNA transposition sites in vitro. J. Mol. Biol. 282: 505-523, 1998.

Chen, B., and Lambowitz, A.M. De novo and DNA primer-mediated initiation of cDNA synthesis by the Mauriceville retroplasmid reverse transcriptase involve recognition of a 3' CCA sequence. J. Mol. Biol. 271, 311-332, 1997.

Chiang, C.-C., and Lambowitz, A.M. The Mauriceville retroplasmid reverse transcriptase initiates cDNA synthesis de novo at the 3' end of tRNAs. Mol. Cell. Biol. 17, 4526-4535, 1997.

Eskes, R., Yang, J., Lambowitz, A.M., and Perlman, P.S. Mobility of yeast mitochondrial group II introns: engineering a new site specificity and retrohoming via full reverse splicing. Cell, 88, 865-874, 1997.

Guo, H., Zimmerly, S., Perlman, P.S., and Lambowitz, A.M. Group II intron endonucleases use both RNA and protein subunits for recognition of specific sequences in double-stranded DNA. EMBO J. 16, 6835-6848, 1997.

Matsuura, M., Saldanha, R., Ma, Hongwen., Wank, H., Yang, J., Mohr, G., Cavanagh, S., Dunny, G.M., Belfort, M., and Lambowitz, A.M. A bacterial group II intron encoding reverse transcriptase, maturase, and DNA endonuclease activities: biochemical demonstration of maturase activity and insertion of new genetic information within the intron. Genes & Devel. 11, 2910-2924, 1997.

Wallweber, G.J., Mohr, S., Rennard, R., Caprara, M.G., and Lambowitz, A.M. Characterization of Neurospora mitochondrial group I introns reveals different CYT-18 dependent and independent splicing strategies and an alternative 3' splice site for an intron ORF. RNA, 3, 114-131, 1997.

Caprara, M.G., Lehnert, V., Lambowitz, A.M., and Westhof, E. A tyrosyl-tRNA synthetase recognizes a conserved tRNA-like structural motif in the group I intron catalytic core, Cell, 87, 1135-1145, 1996.

Caprara, M.G., Mohr, G., and Lambowitz, A.M. A tyrosyl-tRNA synthetase protein induces tertiary folding of the group I intron catalytic core. J. Mol. Biol. 257, 512-531, 1996.

Myers, C.A., Wallweber, G.J., Rennard, R., Kemel, Y., Caprara, M.G., Mohr, G., and Lambowitz, A.M. A tyrosyl-tRNA synthetase suppresses structural defects in the two major helical domains of the group I intron catalytic core. J. Mol. Biol. 262, 87-104, 1996.

Saldanha, R., Ellington, A., and Lambowitz, A.M. Analysis of the CYT-18 protein binding site at the junction of stacked helices in a group I intron RNA by quantitative binding assays and in vitro selection. J. Mol. Biol. 261, 23-42, 1996.

Yang, J., Zimmerly, S., Perlman, P.S., and Lambowitz, A.M. Efficient integration of an intron RNA into double-stranded DNA by reverse splicing, Nature, 381, 332-335, 1996.

Kennell, J.C., Saville, B., Mohr, S., Kuiper, M., Sabourin, J.R., Collins, R.A., and Lambowitz, A.M. The VS catalytic RNA replicates by reverse transcription as a satellite of a retroplasmid. Genes & Dev. 9, 294-303, 1995.

Lambowitz, A.M., and Chiang, C.-C. The Mauriceville and Varkud plasmids: primitive retroelements found in Neurospora mitochondria. Proceedings Fifth International Congress of Mycology, Vancouver, B.C., Canada, August 1994, Can. J. Botany, 73 (Suppl. 1), S173-S179, 1995.

Moran, J.V., Zimmerly, S., Eskes, R., Kennell, J.C., Lambowitz, A.M., Butow, R.A., and Perlman, P.S. Mobile group II introns of yeast mitochondrial DNA are novel site-specific retroelements. Mol. Cell. Biol. 15, 2828-2838, 1995.

Saldanha, R.J., Patel, S.S., Surendran, R., Lee, J.C., and Lambowitz, A.M. Involvement of Neurospora mitochondrial tyrosyl-tRNA synthetase in RNA splicing. A new method for purifying the protein and characterization of physical and enzymatic properties pertinent to splicing. Biochemistry, 34, 1275-1287, 1995.

Zimmerly, S., Guo, H., Eskes, R., Yang, J., Perlman, P.S., and Lambowitz, A.M. A group II intron RNA is a catalytic component of a DNA endonuclease involved in intron mobility, Cell, 83, 529-538, 1995.

Zimmerly, S., Guo, H., Perlman, P.S., and Lambowitz, A.M. Group II intron mobility occurs by target DNA-primed reverse transcription, Cell, 82, 545-554, 1995.

Chiang, C.-C., Kennell, J.C., Wanner, L.A., and Lambowitz, A.M. A mitochondrial retroplasmid integrates into mtDNA by a novel mechanism involving the synthesis of a hybrid cDNA and homologous recombination. Mol. Cell. Biol. 14, 6419-6432, 1994.

Kennell, J.C., Wang, H. and Lambowitz, A.M. The Mauriceville plasmid of Neurospora spp. uses novel mechanisms for initiating reverse transcription in vivo. Mol. Cell. Biol. 14, 3094-3107, 1994.

Mohr, G., Caprara, M.G, Guo, Q., and Lambowitz, A.M. A tyrosyl-tRNA synthetase can function similarly to an RNA structure in the Tetrahymena ribozyme. Nature, 370, 147-150, 1994.

Kennell, J.C., Moran, J.V., Perlman, P.S., Butow, R.A., and Lambowitz, A.M. Reverse transcriptase activity associated with maturase-encoding group II introns in yeast mitochondria. Cell, 73, 133-146, 1993.

Lambowitz, A.M., and Belfort, M. Introns as mobile genetic elements. Annu. Rev. Biochem. 62, 587-622, 1993.

Mohr, G., Perlman, P.S., and Lambowitz, A.M. Evolutionary relationships among group II intron-encoded proteins and identification of a conserved domain that may be related to maturase function. Nucl. Acids Res. 21, 4991-4997, 1993.

Saldanha, R., Mohr, G., Belfort, M., and Lambowitz, A.M. Group I and group II introns. FASEB J. 7, 15-24, 1993.

Wang, H., and Lambowitz, A.M.  Reverse transcription of the Mauriceville plasmid of Neurospora. Lack of RNase H activity associated with the reverse transcriptase and possible use of mitochondrial RNase H. J. Biol. Chem. 268, 18951-18959, 1993.

Wang, H., and Lambowitz, A.M.  The Mauriceville plasmid reverse transcriptase can initiate cDNA synthesis de novo and may be related to reverse transcriptase and DNA polymerase progenitor, Cell, 75, 1071-1081, 1993

Guo, Q., and Lambowitz, A.M.  A tyrosyl-tRNA synthetase binds specifically to the group I intron catalytic core. Genes & Dev. 6, 1357-1372, 1992.

Kämper, U., Kück, U., Cherniack, A.D., and Lambowitz, A.M.  The mitochondrial tyrosyl-tRNA synthetase of Podospora anserina is a bifunctional enzyme active in protein synthesis and RNA splicing. Mol. Cell. Biol. 12, 499-511, 1992.

Mohr, G., Zhang, A., Gianelos, J.A., Belfort, M., and Lambowitz, A.M. The Neurospora CYT-18 protein suppresses defects in the phage T4 td intron by stabilizing the catalytically active structure of the intron core. Cell, 69, 483-494, 1992.

Nargang, F.E., Pande, S., Kennell, J.C., Akins, R.A., and Lambowitz, A.M. Evidence that a 1.6 kilobase region of Neurospora spp. mtDNA was derived by insertion of part of the LaBelle mitochondrial plasmid. Nucl. Acids Res. 20, 1101-1108, 1992.

Turcq, B., Dobinson, K.F., Serizawa, N., and Lambowitz, A.M. A protein required for RNA processing and splicing in Neurospora mitochondria is related to gene products involved in cell cycle protein phosphatase functions. Proc. Natl. Acad. Sci., USA, 89, 1676-1680, 1992.

Wang, H., Kennell, J.C., Kuiper, M.T.R., Sabourin, J.R., Saldanha, R., and Lambowitz, A.M. The Mauriceville plasmid of Neurospora crassa. Characterization of a novel reverse transcriptase that begins cDNA synthesis at the 3' end of template RNA. Mol. Cell. Biol. 12, 5131-5144., 1992.

Guo, Q., Akins, R.A., Garriga, G., and Lambowitz, A.M. Structural analysis of the Neurospora mitochondrial large rRNA intron and construction of a mini-intron that shows protein-dependent splicing. J. Biol. Chem. 266, 1809-1819, 1991.

Kittle, J.D., Jr., Mohr, G., Gianelos, J.A., Wang, H., and Lambowitz, A.M. The Neurospora mitochondrial tyrosyl-tRNA synthetase is sufficient for group I intron splicing in vitro and uses the carboxyl-terminal tRNA-binding domain along with other regions. Genes & Dev. 5, 1009-1021, 1991.

Kubelik, A.R., Turcq, B., and Lambowitz, A.M. The Neurospora crassa cyt-20 gene encodes cytosolic and mitochondrial valyl-tRNA synthetases and may have a second function in addition to protein synthesis. Mol. Cell. Biol. 11, 4022-4035, 1991.

Mohr, G., and Lambowitz, A.M. Integration of a group I intron into a ribosomal RNA sequence promoted by a tyrosyl-tRNA synthetase. Nature, 354, 164-167, 1991.

Schulte, U. and Lambowitz, A.M. The LaBelle mitochondrial plasmid of Neurospora intermedia encodes a novel DNA polymerase that may be derived from a reverse transcriptase. Mol. Cell. Biol. 11, 1696-1706, 1991.

Akins, R.A., and Lambowitz, A.M.  Analysis of large deletions in the Mauriceville and Varkud mitochondrial plasmids of Neurospora. Current Genetics, 18, 365-369, 1990.

Cherniack, A.D., Garriga, G., Kittle, J.D., Akins, R.A., and Lambowitz, A.M. Function of Neurospora mitochondrial tyrosyl-tRNA synthetase in RNA splicing requires an idiosyncratic domain not found in other synthetases. Cell, 62, 745-755, 1990.

Kubelik, A.R., Kennell, J.C., Akins, R.A., and Lambowitz, A.M. Identification of Neurospora mitochondrial promoters and analysis of synthesis of the mitochondrial small rRNA in wild-type and the promoter mutant [poky]. J. Biol. Chem. 265, 4515-4526, 1990.

Kuiper, M.T.R., Sabourin, J.R., and Lambowitz, A.M. Identification of the reverse transcriptase encoded by the Mauriceville and Varkud mitochondrial plasmids of Neurospora. J. Biol. Chem. 265, 6936-6943, 1990.

Lambowitz, A.M., and Perlman, P.S. Involvement of aminoacyl-tRNA synthetases and other proteins in group I and group II intron splicing. TIBS, 15, 440-444, 1990.

Akins, R.A., Kelley, R.L. and, Lambowitz, A.M. Characterization of mutant mitochondrial plasmids of Neurospora spp. that have incorporated tRNAs by reverse transcription. Molec. Cell., Biol. 9, 678-691, 1989.

Dobinson, K.F., Henderson, M., Kelley, R.L., Collins, R.A., and Lambowitz, A.M. Mutations in nuclear gene cyt-4 of Neurospora crassa result in pleiotropic defects in processing and splicing of mitochondrial RNAs. Genetics, 123, 97-108, 1989.

Drygas, M.E., Lambowitz, A.M., and Nargang, F.E. Cloning and analysis of the Neurospora crassa gene for cytochrome c heme lyase. J. Biol. Chem. 264, 17897-17906, 1989.

Kennell, J.C., and Lambowitz, A.M.  Development of an in vitro transcription system for Neurospora mtDNA and identification of transcription initiation sites. Mol. Cell. Biol. 9, 3603-3613, 1989.

Lambowitz, A.M. Infectious introns (Minireview). Cell, 56, 323-326, 1989.

Lambowitz, A.M., Sabourin, J.R., Bertrand, H., Nickels, R., and McIntosh, L. Immunological identification of the alternative oxidase of Neurospora crassa mitochondria. Molec. Cell., Biol. 9, 1362-1364, 1989.

Majumder, A.L., Akins, R.A., Wilkinson, J.G., Kelley, R.L., Snook, A.J., and Lambowitz, A.M. Involvement of tyrosyl-tRNA synthetase in splicing of group I introns in Neurospora crassa mitochondria. Biochemical and immunochemical analysis of splicing activity. Mol. Cell. Biol. 9, 2089-2104, 1989.

Akins, R.A., Grant, D.M., Stohl, L.L., Bottorff, D.A., Nargang, F.E. and Lambowitz, A.M. Nucleotide sequence of the Varkud mitochondrial plasmid of Neurospora and synthesis of a hybrid transcript with a 5' leader derived from mitochondrial RNA. J. Mol. Biol. 204, 1-25, 1988.

Kuiper, M.T.R. and Lambowitz, A.M. A novel reverse transcriptase activity associated with mitochondrial plasmids of Neurospora. Cell, 55, 693-704, 1988.

Kuiper, M.T.R., Akins, R.A., Holtrop, M., de Vries, H. and Lambowitz, A.M. Isolation and analysis of the Neurospora crassa cyt-21 gene: A nuclear gene encoding a mitochondrial ribosomal protein. J. Biol. Chem. 263, 2840-2847, 1988.

Kuiper, M.T.R., Holtrop, M., Venema, H., Lambowitz, A.M., and de Vries, H. A 3' splice site mutation in a nuclear gene encoding a mitochondrial ribosomal protein in Neurospora crassa. J. Biol. Chem. 263, 2848-2852, 1988.

Mann, B.J., Akins, R.A., Lambowitz, A.M., and Metzenberg, R.L. The structural gene for a phosphorus-repressible phosphate permease in Neurospora crassa can complement a mutation in the positive regulatory gene nuc-1. Mol. Cell. Biol. 8, 1376-1379, 1988.

Akins, R.A. and Lambowitz, A.M. A protein required for splicing group I introns in Neurospora mitochondria is mitochondrial tyrosyl-tRNA synthetase or a derivative thereof. Cell, 50, 331-345, 1987.

Paietta, J.V., Akins, R.A., Lambowitz, A.M. and Marzluf, G.A. Molecular cloning of the cys-3+ regulatory gene of Neurospora crassa. Mol. Cell. Biol. 7, 2506-2511, 1987.

Akins, R.A., Kelley, R.L. and Lambowitz, A.M. Mitochondrial plasmids of Neurospora: Integration into mitochondrial DNA and evidence for reverse transcription in mitochondria. Cell, 47, 505-516, 1986.

Garriga, G. and Lambowitz, A.M. Protein-dependent splicing of a group I intron in ribonucleoprotein particles and soluble fractions. Cell, 46, 669-680, 1986.

Garriga, G., Lambowitz, A.M., Inoue, T. and Cech, T.R. Mechanism of recognition of the 5' splice site in self-splicing group I introns. Nature, 352, 86-89, 1986.

Lambowitz, A.M., Akins, R.A., Kelley, R.L., Pande, S. and, Nargang, F.E. Mitochondrial plasmids of Neurospora and other filamentous fungi. In: Extrachromosomal Elements in Lower Eukaryotes (R.B. Wickner, A. Hinnebusch, A.M. Lambowitz, I.C. Gunsalus, and A. Hollaender, eds.), pp. 83-92, Plenum Press Publishers, N.Y., 1986.

Medoff, G., Maresca, B., Lambowitz, A.M., Kobayashi, G., Painter, A., Sacco, M. and Carratu, L. A correlation between pathogenicity and temperature-sensitivity of Histoplasma capsulatum. J. Clin. Invest. 78, 1638-1647, 1986.

Vincent, R.D., Goewert, R., Goldman, W.E., Kobayashi, G.S., Lambowitz, A.M., and Medoff, G. Classification of Histoplasma capsulatum isolates by restriction fragment polymorphisms. J. Bacteriol. 165, 813-818, 1986.

Akins, R.A. and Lambowitz, A.M. A general method for cloning Neurospora crassa nuclear genes by complementation of mutants. Mol. Cell. Biol. 5, 2272-2278, 1985.

Collins, R.A. and Lambowitz, A.M. RNA splicing in Neurospora mitochondria. Defective splicing of mitochondrial mRNA precursors in nuclear mutant cyt18-1. J. Mol. Biol. 184, 413-428, 1985.

Lambowitz, A.M., Akins, R.A., Garriga, G., Henderson, M., Kubelik, A.R., and Maloney, K.A. Mitochondrial introns and mitochondrial plasmids of Neurospora. In: Achievements and Perspectives in Mitochondrial Research. Volume II: Biogenesis (E. Quagliariello et al., eds.), pp. 237-247, Elsevier Science Publishers B.V., Amsterdam, 1985.

Akins, R.A. and Lambowitz, A.M. The poky mutant of Neurospora contains a four base pair deletion at the 5' end of the mitochondrial small rRNA. Proc. Natl. Acad. Sci., USA, 81, 3791-3794, 1984.

Collins, R.A. and Lambowitz, A.M. The physical and genetic map of mitochondrial DNA from Neurospora crassa strain 74-OR23-1A. In: Genetic Maps (S.J. O'Brien, ed.) Vol. III, pp. 274-276, 1984.

Garriga, G. and Lambowitz, A.M. RNA splicing in Neurospora mitochondria. Self-splicing of a mitochondrial intron in vitro. Cell 39, 631-641, 1984.

Garriga, G., Bertrand, H., and Lambowitz, A.M. RNA splicing in Neurospora mitochondria. Nuclear mutants defective in both splicing and 3' end synthesis of the large rRNA. Cell, 36, 623-634, 1984.

Grant, D.M., Lambowitz, A.M., Rambosek, J.A. and Kinsey, J.A. Transformation of Neurospora with recombinant plasmids containing the cloned glutamate dehydrogenase (am) gene. Evidence for autonomous replication of the transforming plasmid. Mol. Cell. Biol. 4, 2041-2051, 1984.

Nargang, F.E., Bell, J.B., Stohl, L.L. and Lambowitz, A.M. The DNA sequence and genetic organization of a Neurospora mitochondrial plasmid suggest a relationship to introns and mobile elements. Cell 38, 441-453, 1984.

Stohl, L.L., Akins, R.A. and Lambowitz, A.M. Characterization of deletion derivative of an autonomously replicating Neurospora plasmid. Nucl. Acids. Res. 12, 6169-6178, 1984.

Collins, R.A. and Lambowitz, A.M. Structural variations and optional introns in the mitochondrial DNAs of Neurospora strains isolated from nature. Plasmid, 9, 53-70, 1983.

Garriga, G. and Lambowitz, A.M. RNA splicing in Neurospora mitochondria. The large rRNA intron contains a noncoded, 5'-terminal guanosine residue. J. Biol. Chem. 258, 14745-14748, 1983.

Lambowitz, A.M., Kobayashi, G.S., Painter, A. and Medoff, G. Possible relationship of morphogenesis in pathogenic fungus, Histoplasma capsulatum, to heat shock response. Nature, 303, 806-808, 1983.

Nargang, F.E., Bell, J.B., Stohl, L.L. and Lambowitz, A.M. A family of repetitive GC-rich palindromic sequences found in Neurospora mitochondrial DNA is also found in a mitochondrial plasmid DNA. J. Biol. Chem. 258, 4257-4260, 1983.

Sacco, M., Medoff, G., Lambowitz, A.M., Kumar, B.V., Kobayashi, G.S. and Painter, A. Sulfhydryl-induced respiratory shunt pathways and their role in morphogenesis in the fungus, Histoplasma capsulatum. J. Biol Chem. 258, 8223-8230, 1983.

Stohl, L.L. and Lambowitz, A.M. A colony filter hybridization procedure for the filamentous fungus, Neurospora crassa. Anal. Biochem. 134, 82-85, 1983.

Stohl, L.L. and Lambowitz, A.M. Construction of a shuttle vector for the filamentous fungus, Neurospora crassa. Proc. Natl. Acad. Sci., USA, 80, 1058-1062, 1983.

Wollenzien, P.L., Cantor, C.R., Grant, D.M. and Lambowitz, A.M. RNA splicing in Neurospora mitochondria. Structure of the unspliced 35S precursor ribosomal RNA detected by psoralen cross-linking. Cell, 32, 397-407, 1983.

Bertrand, H., Bridge, P., Collins, R.A., Garriga, G. and Lambowitz, A.M. RNA splicing in Neurospora mitochondria. Characterization of new nuclear mutants with defects in splicing the mitochondrial large rRNA. Cell, 29, 517-526, 1982.

Collins, R.A., Grant, D.M. and Lambowitz, A.M. The physical and genetic map of mtDNA from Neurospora crassa strain 74-OR23-1A. In: Genetic Maps (S.J. O'Brien, ed.) Vol. II, pp. 206-207, 1982.

Garriga, G., Collins, R.A., Grant, D.M., Lambowitz, A.M., and Bertrand, H. Mitochondrial RNA splicing in Neurospora crassa. In: Mitochondrial Genes (P. Slonimski, P. Borst, and G. Attardi, eds.), pp. 381-390, Cold Spring Harbor Laboratory, New York, 1982.

Grant, D.M. and Lambowitz, A.M., Mitochondrial rRNA genes. In: The Cell Nucleus (H. Busch and L. Rothblum, eds.), Vol. X Part A, pp. 387-408, Academic Press, NY, 1982.

LaPolla, R.J. and Lambowitz, A.M. Mitochondrial ribosome assembly in Neurospora. Structural analysis of mature and partially-assembled ribosomal subunits by equilibrium centrifugation in CsCl gradients. J. Cell Biol. 95, 267-277, 1982.

Stohl, L.L., Collins, R.A., Cole, M.D., and Lambowitz, A.M. Characterization of two new plasmid DNAs found in mitochondria of wild-type Neurospora intermedia strains. Nucl. Acids Res. 10, 1439-1458, 1982.

Collins, R.A. and Lambowitz, A.M. Characterization of a variant Neurospora crassa mitochondrial DNA which contains tandem reiterations of a 1.9 kb sequence. Curr. Genet. 4, 131-133, 1981.

Collins, R.A., Bertrand, H., LaPolla, R.J. and Lambowitz, A.M. A novel extra nuclear mutant of Neurospora with a temperature-sensitive defect in mitochondrial protein synthesis and mitochondrial ATPase. Molec. Gen. Genet. 181, 13-19, 1981.

Collins, R.A., Stohl, L.L., Cole, M.D. and Lambowitz, A.M. Characterization of a novel plasmid DNA found in mitochondria of N. crassa. Cell, 24, 443-452, 1981.

Green, M.R., Grimm, M.F., Goewert, R.R., Collins, R.A., Cole, M.D., Lambowitz, A.M., Heckman, J.E., Yin, S. and, RajBhandary, U.L. Transcripts and processing patterns for the ribosomal RNA and transfer RNA region of Neurospora crassa mitochondrial DNA. J. Biol. Chem. 256, 2027-2034, 1981.

Grimm, M.F., Cole, M.D. and Lambowitz, A.M. RNA splicing in Neurospora mitochondria: Secondary structure of the 35S precursor RNA investigated by digestion with ribonuclease III and by electron microscopy. Biochemistry, 20, 2836-2842, 1981.

LaPolla, R.J. and Lambowitz, A.M. Mitochondrial ribosome assembly in Neurospora. Purification of the mitochondrially-synthesized ribosomal protein, S-5. J. Biol. Chem. 256, 7064-7067, 1981.

Maresca, B., Lambowitz, A.M., Kumar, V.B., Grant, G.A., Kobayashi, G.S. and Medoff, G. Role of cysteine in regulating morphogenesis and mitochondrial activity in the dimorphic fungus Histoplasma capsulatum. Proc. Natl. Acad. Sci., USA, 78, 4596-4600, 1981.

Bertrand, H., Collins, R.A., Stohl, L.L., Goewert, R.R. and, Lambowitz, A.M. Deletion mutants of Neurospora crassa mitochondrial DNA and their relationship to the stop-start growth phenotype. Proc. Natl. Acad. Sci., USA, 77, 6032-6036,1980.

Boynton, J.E., Gillham, N.W., and Lambowitz, A.M. Biogenesis of chloroplast and mitochondrial ribosomes. In: Ribosomes: Structure, Function and Genetics (G. Chamblis, G.R. Craven, J. Davies, K. Davis, L. Kahan and M. Nomura, ed.) pp. 903-950, University Park Press, Baltimore, MD, 1980.

Lambowitz, A.M. Mitochondrial ribosome assembly and RNA splicing in Neurospora crassa. In: The Organization and Expression of the Mitochondrial Genome (A.M. Kroon and C. Saccone, eds.), pp. 291-300, Elsevier/North Holland Biomedical Press, Amsterdam, 1980.

Collins, R.A., Bertrand, H., LaPolla, R.J. and Lambowitz, A.M. Mitochondrial ribosome assembly in Neurospora crassa: Mutants with defects in mitochondrial ribosome assembly. Molec. Gen. Genet. 177, 73-84, 1979.

Grimm, M.F. and Lambowitz, A.M. The 32 S RNA of Neurospora crassa mitochondria is not a precursor of the mitochondrial rRNAs. J. Mol. Biol. 134, 667-672, 1979.

Lambowitz, A.M. Preparation and analysis of mitochondrial ribosomes. In: Methods in Enzymology. Nucleic Acids and Protein Synthesis (part G) (K. Moldave and L. Grossman, eds.), Vol. LIX, pp. 421-433, Academic Press, New York, 1979. (Reprinted in: RNA and Protein Synthesis, (K. Moldave, ed.), pp. 783-795, 1981).

Lambowitz, A.M., LaPolla, R.J. and Collins, R.A. Mitochondrial ribosome assembly in Neurospora. Two-dimensional gel analysis of mitochondrial ribosomal proteins. J. Cell Biol. 82, 17-31, 1979.

LaPolla, R.J. and Lambowitz, A.M. The binding of mitochondrial ribosomal proteins to a mitochondrial ribosomal precursor RNA containing a 2.3 kb intron. J. Biol. Chem. 254, 11746-11750, 1979.

Mannella, C.A. and Lambowitz, A.M. Unidirectional gene conversion associated with two insertions in Neurospora crassa mitochondrial DNA. Genetics, 93, 645-654, 1979.

Mannella, C.A., Collins, R.A., Green, M.R. and Lambowitz, A.M. Defective splicing of mitochondrial rRNA in cytochrome-deficient nuclear mutants of Neurospora crassa. Proc. Natl. Acad. Sci., USA, 76, 2635-2639, 1979.

Mannella, C.A., Goewert, R.R. and Lambowitz, A.M. Characterization of variant Neurospora crassa mitochondrial DNAs which contain tandem reiterations. Cell, 18, 1197-1207, 1979.

Mannella, C.A., Pittenger, T.H. and Lambowitz, A.M. Transmission of mitochondrial DNA in Neurospora crassa sexual crosses. J. Bacteriol. 137, 1449-1451, 1979.

Maresca, B., Lambowitz, A.M., Kobayashi, G.S. and Medoff, G. Respiration in the yeast and mycelial phases of Histoplasma capsulatum. J. Bacteriol. 138, 647-649, 1979.

Lambowitz, A.M. and Zannoni, D. Cyanide-insensitive respiration in Neurospora; genetic and biophysical approaches. In: Plant Mitochondria (G. Ducet and C. Lance, eds.), pp. 283-291, Elsevier/North Holland Biomedical Press, Amsterdam, 1978.

Mannella, C.A. and Lambowitz, A.M. Interaction of wild-type and poky mitochondrial DNA in heterokaryons of Neurospora. Biochem. Biophys. Res. Commun. 80, 673-679, 1978.
 
LaPolla, R.J. and Lambowitz, A.M. Mitochondrial ribosome assembly in Neurospora crassa; chloramphenicol inhibits the maturation of small ribosomal subunits. J. Mol. Biol. 116, 189-205, 1977.

Lambowitz, A.M. The poky mutant of Neurospora crassa. In: Genetics and Biogenesis of Chloroplasts and Mitochondria (Th. Bucher et al., ed.), pp. 713-720, North Holland Publishing Co., Amsterdam, 1976.

Lambowitz, A.M. and Luck, D.J.L. Studies on the poky mutant of Neurospora crassa; fingerprint analysis of mitochondrial ribosomal RNA. J. Biol. Chem. 251, 3081-3095, 1976.

Lambowitz, A.M., Chua, N.H. and Luck, D.J.L. Mitochondrial ribosome assembly in Neurospora crassa; preparation of ribosomal precursor particles, site of synthesis of mitochondrial ribosomal proteins, and studies on the poky mutant. J. Mol. Biol. 107, 223-253, 1976.

Lambowitz, A.M. and Luck, D.J.L. Methylation of mitochondrial RNA species in wild-type and poky strains of Neurospora crassa. J. Mol. Biol. 96, 207-214, 1975

Bonner, W.D., Jr., Lambowitz, A.M. and Wikstrom, M.K.F. On the lack of ATP induced midpoint potential shift in cytochrome b-566 in plant mitochondria. In: Dynamics of Energy-Transducing Membranes (L. Ernster, R.W. Estabrook, and E.C. Slater, ed.), pp. 195-200, Elsevier, Amsterdam, 1974.

Lambowitz, A.M. and Bonner, W.D., Jr. The b-cytochromes of plant mitochondria; a spectrophotometric and potentiometric study. J. Biol. Chem. 249, 2428-2440, 1974.

Lambowitz, A.M. and Bonner, W.D., Jr. The b cytochromes of plant mitochondria. In: Dynamics of Energy-Transducing Membranes (L. Ernster, R.W. Estabrook, and E.C. Slater, eds.), pp. 77-92, Elsevier, Amsterdam, 1974.

Lambowitz, A.M. and Bonner, W.D., Jr. The mitochondrial b-cytochromes of the wild-type and poky strains of Neurospora crassa; evidence for a component reduced only by dithionite. J. Biol. Chem. 249, 2886-2890, 1974.

Lambowitz, A.M., Bonner, W.D., Jr. and Wikstrom, M.K.F. On the lack of ATP induced midpoint potential shift for cytochrome b-566 in plant mitochondria. Proc. Natl. Acad. Sci., USA, 71, 1183-1187, 1974.

Wikstrom, M.K.F. and Lambowitz, A.M. The interaction of redox mediators with the second phosphorylation site; significance for the cytochrome bT hypothesis. FEBS Lett. 40, 149-153, 1974.

Lambowitz, A.M. and Bonner, W.D., Jr. The effect of antimycin on the b-cytochromes of plant mitochondria; oxidation-reduction behavior of cytochrome b-566. Biochem. Biophys. Res. Commun. 52, 703-711, 1973.

Lambowitz, A.M. and Slayman, C.W. Effect of pyrrolnitrin on electrontransport and oxidative phosphorylation in mitochondria isolated from Neurospora crassa. J. Bacteriol. 112, 1020-1022, 1972.

Lambowitz, A.M., Slayman, C.W., Slayman, C.L. and Bonner, W.D., Jr. The electron transport components of the wild-type and poky strains of Neurospora crassa. J. Biol. Chem. 247, 1536-1545, 1972.

Lambowitz, A.M., Smith, E.W. and Slayman, C.W. Electron transport in Neurospora mitochondria; studies on wild type and poky. J. Biol. Chem. 247, 4850-4858, 1972.

Lambowitz, A.M., Smith, E.W. and Slayman, C.W. Oxidative phosphorylation in Neurospora mitochondria; studies on wild type, poky, and chloramphenicol-induced wild type. J. Biol. Chem. 247, 4859-4865, 1972.

Lambowitz, A.M. and Slayman, C.W. Cyanide-resistant respiration in Neurospora crassa. J. Bacteriol. 108, 1087-1096, 1971.